Recent Advances in Carbon Nanotubes as Delivery Systems for Anticancer Drugs

Daniela      Iannazzo; Anna      Piperno; Alessandro      Pistone; Giovanni      Grassi; Signorino      Galvagno

doi:10.2174/0929867311320110001

Abstract

Problems associated with the administration of anticancer drugs, such as limited solubility, poor biodistribution, lack of selectivity, and healthy tissue damage, can be overcome by the implementation of drug delivery systems. A wide range of materials, including liposomes, microspheres, polymers and recently, carbon nanotubes (CNTs), have been investigated for delivering anticancer drugs on the purpose of reducing the number of necessary administrations, providing more localized and better use of the active agents, and increasing patient compliance. Carbon nanotubes (CNTs) have attracted particular attention as carriers of biologically relevant molecules due to their unique physical, chemical and physiological properties. The exact relationship between the physical–chemical properties of carbon nanotubes, their cellto- cell interactions, reactivity, and biological/systemic consequences are relevant issues and it is important to know such inter-relationships beforehand to employ the benefits of these nanomaterials without the hazardous consequences. The purpose of this review is to present highlight of recent developments in the application of carbon nanotubes as cargoes for anticancer drugs and in the diagnosis of cancer diseases.

Keywords: Carbon nanotubes, anticancer drugs, drug delivery systems.