A Systematic Review of Tissue Engineered Meniscus and Replacement Strategies: Preclinical Models

Title:A Systematic Review of Tissue Engineered Meniscus and Replacement Strategies: Preclinical Models

Volume: 8 Issue: 3

Author(s): Behrooz Haddad, Behzad Haddad, Sujith Konan, Adetola Adesida and Wasim S. Khan

Affiliation:

Keywords: Meniscus, tissue engineering, systematic review, meniscal replacement, mesenchymal stem cells

Abstract: Meniscal injuries are among the common sports injuries and their natural healing is limited. Removal of injured meniscus impairs normal knee function and predisposes patients to osteoarthritis. Tissue engineering and replacement strategies provide a novel approach for the treatment of severe meniscus injury. The aim of this article is to review preclinical studies that used approaches for meniscal replacement including growth factors, synthetic and tissue engineered scaffolds and non-meniscal autografts. Medline, EMBASE and UK PubMed search was performed and articles were assessed for inclusion. Included articles were summarised and categorised. Forty seven articles matched the inclusion criteria. The studies were classified according to the approaches used for meniscus replacement. Overall most experiments have shown good tissue integration and biochemical properties of the regenerated tissues. However, only few approaches have demonstrated satisfactory chondroprotective function.

Cite this article as:

Haddad Behrooz, Haddad Behzad, Konan Sujith, Adesida Adetola and S. Khan Wasim, A Systematic Review of Tissue Engineered Meniscus and Replacement Strategies: Preclinical Models, Current Stem Cell Research & Therapy 2013; 8 (3) . https://dx.doi.org/10.2174/1574888X11308030008