Taxol: Efficacy Against Oral Squamous Cell Carcinoma

Kaitlyn      Ledwitch; Ryenne      Ogburn; Jodi      Cox; Rebekah      Graham; Allison      Fritzsche; Donna      Gosnell; Thomas      Manning

doi:10.2174/1389557511313040004

Abstract

In medicinal chemistry, one of the most studied molecules in recent history is taxol. Taxol is a versatile natural product that is used in various cancer treatment regimens. It is administered to patients with breast, lung, and ovarian cancers, and is currently being studied for the treatment of squamous cell carcinoma of the oral cavity and tongue. Taxol has been tested in a number of research and clinical phase trials to determine feasibility, toxicity, and cytotoxicity against oral squamous cell carcinoma as a single drug regimen and as a contributing drug component in treatment plans. This paper reviews over forty articles that examine cell lines, murine models, and human results for the response of taxol against squamous cell carcinoma (SCC) of the oral cavity and the tongue.

Keywords: 5-fluorouracil (5-FU), cisplatin, carboplatin, hydroxyurea, hyaluronic acid oral squamous cell carcinoma (OSCC), oxaliplatin, paclitaxel, taxol, oral cancer, tongue cancer,