Structure and Thermodynamics of Drug-RNA Aptamer Interactions

J.      B. Da Costa; T.      Dieckmann

doi:10.2174/1389557511313040001

Abstract

This mini-review will provide an overview on the recent studies of structure and thermodynamics of RNA aptamers that target drug molecules. These aptamers are studied to provide insight into RNA drug interactions. This interaction is important due to the many roles RNA plays in cell biology.

Keywords: Ribonucleic acid, aptamer, thermodynamics, isothermal titration calorimetry, RNA structure, in vitro, PEG, AUCGCA loop