Abstract
Bacteria commonly communicate with each other by a cell-to-cell signaling mechanism known as quorum sensing, using soluble mediators. Recent studies showed that these molecules target not only bacteria, but also interact with the eukaryotic host. Pseudomonas aeruginosa infection occurs both in acute or chronic states in a variety of respiratory and urinary infections. These infections are often difficult to treat, and numerous therapeutic options, besides antibiotics, have been searched. In this context quorum-sensing inhibitors could represent an attractive potential therapeutic strategy with promising results.
Keywords: Autoinducers, Host-pathogen relationship, Immunomodulation, Inter-kingdom communication, Pseudomonas aeruginosa, Quorum sensing
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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