Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

Annalaura      Barbieri; Claudio      Franceschi; Miriam      Capri; Aurelia      Santoro; Fiammetta      Biondi; Maria      Scurti; Elisa      Pini; Elisa      Cevenini; Morena      Martucci; Elena      Bellavista; Dario      Vianello; Vincenzo      Borelli; Laura      Lomartire; Stefano      Salvioli; Stella      Lukas Yani; Federica      Sevini; Laura      Bucci; Rita      Ostan; Elisa      Fontanesi; Cristina      Giuliani; Paolo      Garagnani; Maria      Giulia Bacalini; Chiara      Pirazzini; Maria      Conte; Catia      Lanzarini; Daniela      Monti

doi:10.2174/1381612811319090015

Abstract

Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm- aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.

Keywords: Inflammation, aging, centenarians, cell senescence, immunosenescence, immunological stimuli, pro-inflammatory mediators, markers, inflamm-aging, longevity