Functional Nanoplatforms for Enhancement of Chemotherapeutic Index

Title:Functional Nanoplatforms for Enhancement of Chemotherapeutic Index

Volume: 13 Issue: 2

Author(s): Jaemoon Yang, Eugene Lee, Minhee Ku, Yong-Min Huh and Jae-Ho Cheong

Affiliation:

Keywords: Anti-cancer agents, Cancer, Combination chemotherapy, Nanoparticle, Synergistic effect

Abstract: Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.

Cite this article as:

Yang Jaemoon, Lee Eugene, Ku Minhee, Huh Yong-Min and Cheong Jae-Ho, Functional Nanoplatforms for Enhancement of Chemotherapeutic Index, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (2) . https://dx.doi.org/10.2174/1871520611313020005