A QSAR Study on Some Series of Anticancer Tyrosine Kinase Inhibitors

Title:A QSAR Study on Some Series of Anticancer Tyrosine Kinase Inhibitors

Volume: 9 Issue: 2

Author(s): Zaihra Anwer and Satya P. Gupta

Affiliation:

Keywords: Quantitative structure-activity relationship, Tyrosine kinase inhibitors, Lck inhibitors, Endothelial growth factor receptor (EGFR), 4-alkynylquinazolines, 4-alkenylquinazolines, N-4, 6-pyrimidine-N-alkyl-N’-phenyl ureas.

Abstract: A quantitative structure-activity relationship (QSAR) study has been made on two different series of anticancer tyrosine kinase inhibitors, namely a series of 4-alkynyl and 4-alkenyl-quinazolines and a series of N-4,6-pyrimidine-Nalkyl- N'-phenyl ureas. For the first series, QSAR results indicate that the activity is controlled by the hydrophobicity of the molecules and molecular connectivity index of the substituent, whereas for the second series of compounds the activity is found to be controlled by the molecular connectivity index of the substituent and some indicator variables.

Cite this article as:

Anwer Zaihra and P. Gupta Satya, A QSAR Study on Some Series of Anticancer Tyrosine Kinase Inhibitors, Medicinal Chemistry 2013; 9 (2) . https://dx.doi.org/10.2174/1573406411309020005