An overview of ABC and SLC Drug Transporter Gene Regulation

Title:An overview of ABC and SLC Drug Transporter Gene Regulation

Volume: 14 Issue: 2

Author(s): Qiu-Xia Chen, Hai-Hong Hu, Quan Zhou, Ai-Ming Yu and Su Zeng

Affiliation:

Keywords: drug disposition, transporters, nuclear receptors, transcription factors, signaling pathways, xenobiotics, cytokines, ABC and SLC, Drug Transporter, Gene Regulation, Disposition, Na+/K+-ATPase, MATE, CREB-binding protein, ABCC, MDR1 Expression, BCRP

Abstract: Membrane transporters play a significant role in drug absorption, distribution and excretion, and they consequently affect the pharmacokinetics, efficacy and safety of a drug. Under certain circumstances, such as pathological processes or exposure to certain substances, the expression of drug transporters is modified in cells. Change in transporter expression and function may affect cellular drug disposition resulting in different drug responses. This raises a number of questions such as which drugs are likely to modulate the expression of drug transporters, what factors support this process, and which transporters are influenced in a particular situation. In this paper, we summarize recent findings to find an answer to these questions. Particularly, we present an overview of the transcription factors involved in the regulation of a given drug transporter, the signaling transduction pathways that contribute to drug transporter gene expression, and xenobiotics and endobiotics that initiate the processes.

Cite this article as:

Chen Qiu-Xia, Hu Hai-Hong, Zhou Quan, Yu Ai-Ming and Zeng Su, An overview of ABC and SLC Drug Transporter Gene Regulation, Current Drug Metabolism 2013; 14 (2) . https://dx.doi.org/10.2174/1389200211314020013