Alteration of the Beta-Adrenergic Signaling Pathway in Human Heart Failure

Title:Alteration of the Beta-Adrenergic Signaling Pathway in Human Heart Failure

Volume: 13 Issue: 13

Author(s): Nazha Hamdani and Wolfgang A. Linke

Affiliation:

Keywords: Heart failure, β adrenergic receptors, myofilament proteins, cardiomyocytes

Abstract: Heart failure is characterized by elevated circulating catecholamine levels and extensive abnormalities in β-adrenergic receptor signaling. Under physiological conditions, sympathetic modulation via catecholamines induces positive inotropic, chronotropic and lusitropic responses. Well established in heart failure patients is a pronounced activation of the sympathetic system, accompanied by downregulation and desensitization of β-adrenergic receptors, leading to a markedly diminished β-adrenergic contractile response. In this review, we will discuss the normal β-adrenergic receptor signaling pathway in the heart and focus on the pathphysiological alterations of β-adrenergic receptor signaling and contractile proteins in heart failure.

Cite this article as:

Hamdani Nazha and A. Linke Wolfgang, Alteration of the Beta-Adrenergic Signaling Pathway in Human Heart Failure, Current Pharmaceutical Biotechnology 2012; 13 (13) . https://dx.doi.org/10.2174/1389201011208062522