Adenovirus/PSA (Ad5-PSA) Vaccination for Prostate Cancer: Pre-Clinical and Clinical Development

Title:Adenovirus/PSA (Ad5-PSA) Vaccination for Prostate Cancer: Pre-Clinical and Clinical Development

Volume: 8 Issue: 4

Author(s): Daniel Vaena and David Lubaroff

Affiliation:

Keywords: Ad5-PSA vaccine, prostate cancer, immunotherapy

Abstract: The use of PSA (prostate-specific antigen) for its diagnostic utility in prostate cancer is a subject of discussion; however, due to its specificity to the prostate tissue, PSA remains a potential immunotherapy target. We developed a PSA-recombinant viral vector, adenovirus5-PSA (Ad5-PSA) that generated vigorous PSA-specific immune and antitumor responses in a prostate cancer mouse model. Using Ad5-PSA vaccine we successfully completed a Phase I clinical study and are conducting a Phase II trial. In this review, we summarize the clinical development of this Ad5-PSA vaccine as an immunotherapeutic agent and its potential utility for the treatment of prostate cancer.

Cite this article as:

Vaena Daniel and Lubaroff David, Adenovirus/PSA (Ad5-PSA) Vaccination for Prostate Cancer: Pre-Clinical and Clinical Development, Current Cancer Therapy Reviews 2012; 8 (4) . https://dx.doi.org/10.2174/1573394711208040271