An Efficient Catalyst System for the Synthesis of N-(p-benzoylaminoaryl)- N'-Boc Piperazines Under Microwave Conditions

Mule      S. Reddy; Peruri      V. V. Satyanarayana; Bollikolla      Haribabu

doi:10.2174/157017812803901935

Abstract

We have developed a new combination of catalyst system for the synthesis of N-(p-benzoylaminoaryl)-N'-Boc piperazines under microwave conditions (Biotage, 300 Watt) in the presence of sodium tert-butoxide and in DMF. The catalyst and ligand used are Tris (dibenzylideneacetone) dipalladium(0) and 2-Dicyclohexylphosphino-2-(N,Ndimethylamino) biphenyl (Dave Phos) respectively, the desired N-(p-benzoylaminoaryl)-N'-Boc Piperazines was obtained in good yields (80-92%).

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Letters in Organic Chemistry

Title:An Efficient Catalyst System for the Synthesis of N-(p-benzoylaminoaryl)- N'-Boc Piperazines Under Microwave Conditions

Volume: 9 Issue: 10

Author(s): Mule S. Reddy, Peruri V. V. Satyanarayana and Bollikolla Haribabu

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Abstract: We have developed a new combination of catalyst system for the synthesis of N-(p-benzoylaminoaryl)-N'-Boc piperazines under microwave conditions (Biotage, 300 Watt) in the presence of sodium tert-butoxide and in DMF. The catalyst and ligand used are Tris (dibenzylideneacetone) dipalladium(0) and 2-Dicyclohexylphosphino-2-(N,Ndimethylamino) biphenyl (Dave Phos) respectively, the desired N-(p-benzoylaminoaryl)-N'-Boc Piperazines was obtained in good yields (80-92%).

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S. Reddy Mule, V. V. Satyanarayana Peruri and Haribabu Bollikolla, An Efficient Catalyst System for the Synthesis of N-(p-benzoylaminoaryl)- N'-Boc Piperazines Under Microwave Conditions, Letters in Organic Chemistry 2012; 9 (10) . https://dx.doi.org/10.2174/157017812803901935