Microwave-Assisted Multicomponent Reactions of Alkyl Bromides: Synthesis of Thiophene Derivatives

Faramarz      Rostami-Charati; Asadollah      Hassankhani; Zinatossadat      Hossaini

doi:10.2174/138620712803901162

Abstract

A series of thiophene derivatives were synthesized via one-pot multicomponent reactions of alkyl bromids, aroyl or alkanoyl isothiocyanates, 1,3-dicarbonyl compounds and secondary amins under microwave irradiation at 80 °C. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.

Keywords: Acetyl acetone, carbonyl compounds, dimedone, microwave conditions, thiophen.

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Combinatorial Chemistry & High Throughput Screening

Title:Microwave-Assisted Multicomponent Reactions of Alkyl Bromides: Synthesis of Thiophene Derivatives

Volume: 15 Issue: 10

Author(s): Faramarz Rostami-Charati, Asadollah Hassankhani and Zinatossadat Hossaini

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Keywords: Acetyl acetone, carbonyl compounds, dimedone, microwave conditions, thiophen.

Abstract: A series of thiophene derivatives were synthesized via one-pot multicomponent reactions of alkyl bromids, aroyl or alkanoyl isothiocyanates, 1,3-dicarbonyl compounds and secondary amins under microwave irradiation at 80 °C. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.

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Rostami-Charati Faramarz, Hassankhani Asadollah and Hossaini Zinatossadat, Microwave-Assisted Multicomponent Reactions of Alkyl Bromides: Synthesis of Thiophene Derivatives, Combinatorial Chemistry & High Throughput Screening 2012; 15 (10) . https://dx.doi.org/10.2174/138620712803901162