One-Pot Approach to 4-Vinyl-1,2,3-Triazoles by Cycloaddition of Azides with Propargyl Alcohols Catalyzed by Cu(I)/Ru(III)/TFA

Ji      Su; Ruimao      Hua

doi:10.2174/157017912803901646

Abstract

An efficient and regioselective one-pot direct synthesis of 4-vinyl-1,2,3-triazoles via cycloaddition of azides with propargyl alcohols and dehydration catalyzed by a CuCl/RuCl3·3H2O bimetallic catalysts in the presence of TFA (Trifluoroacetic acid) is developed.

Keywords: Azides, Cuprous chloride, Propargyl alcohols, Ruthenium trichloride hydrate, 4-Vinyl-1, 2, 3-triazoles, Trifluoroacetic acid.

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Current Organic Synthesis

Title:One-Pot Approach to 4-Vinyl-1,2,3-Triazoles by Cycloaddition of Azides with Propargyl Alcohols Catalyzed by Cu(I)/Ru(III)/TFA

Volume: 9 Issue: 6

Author(s): Ji Su and Ruimao Hua

Affiliation:

Keywords: Azides, Cuprous chloride, Propargyl alcohols, Ruthenium trichloride hydrate, 4-Vinyl-1, 2, 3-triazoles, Trifluoroacetic acid.

Abstract: An efficient and regioselective one-pot direct synthesis of 4-vinyl-1,2,3-triazoles via cycloaddition of azides with propargyl alcohols and dehydration catalyzed by a CuCl/RuCl3·3H2O bimetallic catalysts in the presence of TFA (Trifluoroacetic acid) is developed.

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Su Ji and Hua Ruimao, One-Pot Approach to 4-Vinyl-1,2,3-Triazoles by Cycloaddition of Azides with Propargyl Alcohols Catalyzed by Cu(I)/Ru(III)/TFA, Current Organic Synthesis 2012; 9 (6) . https://dx.doi.org/10.2174/157017912803901646