Synthesis of Biologically Active Bridged Diazabicycloheptanes

G.      Murineddu; B.      Asproni; G.      Pinna; M.M.      Curzu; A.      Dore; A.      Pau; F.      Deligia; G.A.      Pinna

doi:10.2174/092986712803833317

Abstract

The chemistry underlying how diazabicycloheptanes are assembled is described, subdivided according to chemical structure of two types, the 3,6 diazabicyclo[3.1.1]heptane and the 2,5-diazabicyclo[2.2.1]heptane ring system. Detailed information on myriad of activities of compounds derived from the two scaffolds are reported.

Keywords: 3, 6-diazabicyclo[3.1.1]heptanes, 2, 5-diazabicyclo[2.2.1]heptanes, synthesis, antibacterial activity, antitumor activity, antiinflammatory activity, analgesic activity, antipsychotic activity, ischemic injuries, obesity

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Current Medicinal Chemistry

Title:Synthesis of Biologically Active Bridged Diazabicycloheptanes

Volume: 19 Issue: 31

Author(s): G. Murineddu, B. Asproni, G. Pinna, M.M. Curzu, A. Dore, A. Pau, F. Deligia and G.A. Pinna

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Abstract: The chemistry underlying how diazabicycloheptanes are assembled is described, subdivided according to chemical structure of two types, the 3,6 diazabicyclo[3.1.1]heptane and the 2,5-diazabicyclo[2.2.1]heptane ring system. Detailed information on myriad of activities of compounds derived from the two scaffolds are reported.

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Murineddu G., Asproni B., Pinna G., Curzu M.M., Dore A., Pau A., Deligia F. and Pinna G.A., Synthesis of Biologically Active Bridged Diazabicycloheptanes, Current Medicinal Chemistry 2012; 19 (31) . https://dx.doi.org/10.2174/092986712803833317