Abstract
Molecules containing 3-substituted isobenzofuranones and isoindolinones skeletons are found in important bioactive compounds and in a number of natural products. As a consequence several synthetic strategies, both asymmetric and non-asymmetric, have been developed. Thus, this review focuses on the main synthetic approaches to obtain these classes of compounds, analysing the common features, the scope and the limitations and at the same time giving particular emphasis to the role of active methylene compounds.
Keywords: Heterocyclic compounds, Bioactive compounds, Active methylene compounds, Tandem reactions, Organocatalysis, Metal catalysts, Aldol reactions, Multi-component reactions, 1, 3-dicarbonyl, hydroxymethylation, formaldehyde
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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