A Highly Efficient Green Synthesis of N-Alkyl 2-[(2-Oxo-2-Aryl Ethyl) Amino] Benzamide Derivatives from Reaction of Isatoic Anhydride, Primary Amines and 2-Bromoacethophenone

Title:A Highly Efficient Green Synthesis of N-Alkyl 2-[(2-Oxo-2-Aryl Ethyl) Amino] Benzamide Derivatives from Reaction of Isatoic Anhydride, Primary Amines and 2-Bromoacethophenone

Volume: 15 Issue: 9

Author(s): Maryam Sabbaghan and Zinatossadat Hossaini

Affiliation:

Keywords: 2-bromoacethophenone, Benzamide, green synthesis, one-pot synthesis, solvent-free, Isatoic Anhydride, Primary Amines, Diversity-oriented synthesis (DOS), heterocycles compound, pharmacological properties

Abstract: N-alkyl 2-[(2-oxo-2-aryl ethyl)amino] benzamide derivatives have been synthesized in high yields. This involves three-component reaction of isatoic anhydride, primary amines in the presence of 2-bromoacethophenone derivatives. The reaction workup is simple and the products can be easily separated from the reaction mixture.

Cite this article as:

Sabbaghan Maryam and Hossaini Zinatossadat, A Highly Efficient Green Synthesis of N-Alkyl 2-[(2-Oxo-2-Aryl Ethyl) Amino] Benzamide Derivatives from Reaction of Isatoic Anhydride, Primary Amines and 2-Bromoacethophenone, Combinatorial Chemistry & High Throughput Screening 2012; 15 (9) . https://dx.doi.org/10.2174/138620712803519716