Chronopharmaceutics Based Modern Colon Specific Drug Delivery Systems

Akanksha      Tiwari; Raj      Kumar Shukla; Suresh      Tiwari; Surti      Naazneen

doi:10.2174/157016312803305889

Abstract

Colon-targeted delivery of bioactives has recently gained importance in addressing specific needs in the therapy of colon based diseases. Many approaches have been attempted for the development of colon-specific delivery systems, with not much success in the past. With the advancement in the field of chronobiology, modern drug delivery approaches have elevated to a new concept of chronopharmacology i.e. the ability to deliver the therapeutic agent to a patient in a staggered profile. The increasing research interest surrounding this delivery system has widened the areas of pharmaceutics in particular with many more sub-disciplines expected to coexist in the near future. Chronopharmaceutics based technology has eliminated the drawbacks associated with the conventional colon specific delivery systems. This review on chronopharmaceutics based delivery lays emphasis on the existing technologies and future development.

Keywords: Colon-targeted delivery, chronopharmaceutics, drug delivery systems, modern technology, drug dosage, chronobiology, drug release, ulcerative colitis, Crohn’s disease, colorectal cancer