Immunotherapy with Tumor Vaccines for the Treatment of Malignant Gliomas

Title:Immunotherapy with Tumor Vaccines for the Treatment of Malignant Gliomas

Volume: 9 Issue: 4

Author(s): Divya Ajay, Luis Sanchez-Perez, Bryan D. Choi, Gabriel De Leon and John H. Sampson

Affiliation:

Keywords: Immunotherapy, Glioma, Vaccines, tumor cells, Glioblastoma multiforme (GBM), immunosuppression, central nervous system, CD8+ cells, immune system, HLA molecules

Abstract: With an average life expectancy of 14 months, Glioblastoma multiforme (GBM), is the most aggressive primary brain tumor. Our growing understanding of the immune system and its role in oncogenesis has helped develop cancer vaccines as a promising treatment modality against this disease. What follows is a comprehensive discussion on the history of immunotherapy and the various vaccine based therapies being developed and utilized for the treatment of malignant gliomas.

Cite this article as:

Ajay Divya, Sanchez-Perez Luis, D. Choi Bryan, De Leon Gabriel and H. Sampson John, Immunotherapy with Tumor Vaccines for the Treatment of Malignant Gliomas, Current Drug Discovery Technologies 2012; 9 (4) . https://dx.doi.org/10.2174/157016312803305933