Peptides As Therapeutics with Enhanced Bioactivity

Title:Peptides As Therapeutics with Enhanced Bioactivity

Volume: 19 Issue: 26

Author(s): D. Goodwin, P. Simerska and I. Toth

Affiliation:

Keywords: Peptide, drug delivery, vaccine, manufacture, bioavailability, peptide therapeutic, immunogenicity, peptide drug, peptide synthesis, clinical trials.

Abstract: The development of techniques for efficient peptide production renewed interest in peptides as therapeutics. Numerous modifications for improving stability, transport and affinity profiles now exist. Several new adjuvant and carrier systems have also been developed, enhancing the immunogenicity of peptides thus allowing their development as vaccines. This review describes the established and experimental approaches for manufacturing peptide drugs and highlights the techniques currently used for improving their drug like properties.

Cite this article as:

Goodwin D., Simerska P. and Toth I., Peptides As Therapeutics with Enhanced Bioactivity, Current Medicinal Chemistry 2012; 19 (26) . https://dx.doi.org/10.2174/092986712803251548