Invasive aspergillosis: adjunctive combination therapy

Title:Invasive aspergillosis: adjunctive combination therapy

Volume: 12 Issue: 12

Author(s): Sonam Ruhil, Meenakshi Balhara, Sandeep Dhankhar, Vikash Kumar and A.K. Chhillar

Affiliation:

Keywords: Aspergillus, Aspergillosis, Adjunctive agent, Combination therapy, Monotherapy.

Abstract: Invasive aspergillosis remains a serious opportunistic fungal infection particularly in patients with a reduced immune defense such as those with hematological malignancies or transplant recipients. The mortality of invasive infections due to Aspergillus spp. is still high. The main reasons for this are the difficulty in diagnosing of these infections and the limited efficacy of antifungal agents. There is no optimal therapy for invasive aspergillosis, and therefore many clinicians have attempted to utilize a combination approach to improve outcomes. The current antifungal classes of drugs targeting the cell wall and cell membrane may need adjunctive agents focused on separate cellular pathways that can be used in combination therapy to maximize the efficacy, a valuable alternative to the monotherapy. The endeavor of this article is to review the literature on combination therapy by using adjunctive agents against Aspergillus spp and assess its eventual usability in the treatment of invasive aspergillosis.

Cite this article as:

Ruhil Sonam, Balhara Meenakshi, Dhankhar Sandeep, Kumar Vikash and Chhillar A.K., Invasive aspergillosis: adjunctive combination therapy, Mini-Reviews in Medicinal Chemistry 2012; 12 (12) . https://dx.doi.org/10.2174/138955712802762086