PEG-Mediated Catalyst-Free Expeditious Synthesis of Polysubstituted Anilines and Benzenes via the Reaction of Malononitrile and β-Ketoester Derivatives in the Presence of Activated Acetylenes

Title:PEG-Mediated Catalyst-Free Expeditious Synthesis of Polysubstituted Anilines and Benzenes via the Reaction of Malononitrile and β-Ketoester Derivatives in the Presence of Activated Acetylenes

Volume: 15 Issue: 7

Author(s): Mohammad Piltan, Loghman Moradi, Hiwa Salimi, Kiomars Zargoosh and Seyed Amir Zarei

Affiliation:

Keywords: Activated acetylenes, functionalized anilines and benzenes, malononitrile, PEG, β-ketoester, green chemistry, Catalyst-Free, solvent-free techniques, Aromatic amines, cyanoanilines

Abstract: Poly(ethylene glycol) (PEG) has been used as a sustainable, non-volatile, and environmentally friendly reaction solvent for synthesis of functionalized anilines and benzenes via the reaction of malononitrile and β-ketoester derivatives in the presence of activated acetylenes at 80o C. No additional solvent and catalyst are required.

Cite this article as:

Piltan Mohammad, Moradi Loghman, Salimi Hiwa, Zargoosh Kiomars and Amir Zarei Seyed, PEG-Mediated Catalyst-Free Expeditious Synthesis of Polysubstituted Anilines and Benzenes via the Reaction of Malononitrile and β-Ketoester Derivatives in the Presence of Activated Acetylenes, Combinatorial Chemistry & High Throughput Screening 2012; 15 (7) . https://dx.doi.org/10.2174/138620712801619195