Highly Efficient One Step Synthesis of Primary Amines from B-Chlorodialkylboranes

Sanjay      V. Malhotra; Herbert      C. Brown

doi:10.2174/157017812801322453

Abstract

A convenient and simple method for synthesis of primary amines has been developed by direct amination of B- Chlorodialkylboranes. This general procedure has been applied to synthesize acyclic, cyclic, hindered and chiral amines in very high yields using both hydroxylamine-O-sulfonic acid and monochloroamine as reagents.

Keywords: Amination, B-Chlorodialkylboranes, chiral amine, organoborane, hydroxy-lamine-O-sulfonic, nitrogen, alkyl group, methyldialkylborane, chlorodialkylborane, water

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Letters in Organic Chemistry

Title:Highly Efficient One Step Synthesis of Primary Amines from B-Chlorodialkylboranes

Volume: 9 Issue: 6

Author(s): Sanjay V. Malhotra and Herbert C. Brown

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Keywords: Amination, B-Chlorodialkylboranes, chiral amine, organoborane, hydroxy-lamine-O-sulfonic, nitrogen, alkyl group, methyldialkylborane, chlorodialkylborane, water

Abstract: A convenient and simple method for synthesis of primary amines has been developed by direct amination of B- Chlorodialkylboranes. This general procedure has been applied to synthesize acyclic, cyclic, hindered and chiral amines in very high yields using both hydroxylamine-O-sulfonic acid and monochloroamine as reagents.

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V. Malhotra Sanjay and C. Brown Herbert, Highly Efficient One Step Synthesis of Primary Amines from B-Chlorodialkylboranes, Letters in Organic Chemistry 2012; 9 (6) . https://dx.doi.org/10.2174/157017812801322453