Preparation, Chemical and Electrical Characterizations of Lipid Nanoparticles Loaded with Dihydroxybenzophenone

Title:Preparation, Chemical and Electrical Characterizations of Lipid Nanoparticles Loaded with Dihydroxybenzophenone

Volume: 8 Issue: 4

Author(s): Hierrezuelo Jesus, Benavente Juana, Lopez–Romero Juan Manuel, Martinez de Yuso Maria del Valle and Rodriguez–Castellon Enrique

Affiliation:

Keywords: Lipid nanoparticles, 2, 4-dihydroxybenzophenone, homogenizer, ultrasounds, SEM, XPS, impedance spectroscopy, photoelectron, atomic force microscopy

Abstract: Lipid nanoparticles loading the sunscreen 2,4-dihydroxybenzophenone (DHB-LNPs) have been prepared by high-pressure homogenization and ultrasound techniques. The combination of both methodologies improves the entrapment efficiency percentage reaching 95%. The morphology of the DHB-LNPs was studied with scanning electron microscopy (SEM) and atomic force microscopy (AFM), while the surface and interior chemical composition was analyzed by X-ray photoelectron spectroscopy (XPS) at different irradiation times. Conductivity of aqueous dispersions of the DHBLNPs was determined by impedance spectroscopy. A possible DHB-LNPs application related to drug release in a system simulating skin-properties is shown.

Cite this article as:

Jesus Hierrezuelo, Juana Benavente, Juan Manuel Lopez–Romero, de Yuso Maria del Valle Martinez and Enrique Rodriguez–Castellon, Preparation, Chemical and Electrical Characterizations of Lipid Nanoparticles Loaded with Dihydroxybenzophenone, Medicinal Chemistry 2012; 8 (4) . https://dx.doi.org/10.2174/157340612801216238