2,4,6-Trichlorophenylhydrazine Schiff Bases as DPPH Radical and Super Oxide Anion Scavengers

Khalid      Mohammed Khan; Zarbad      Shah; Viqar      Uddin Ahmad; Momin      Khan; Muhammad      Taha; Fazal      Rahim; Sajjad      Ali; Nida      Ambreen; Shahnaz      Perveen; M.      Iqbal Choudhary; Wolfgang      Voelter

doi:10.2174/1573406411208030452

Abstract

Syntheses of thirty 2,4,6-trichlorophenylhydrazine Schiff bases 1-30 were carried out and evaluated for their in vitro DPPH radical and super oxide anion scavenging activities. Compounds 1-30 have shown a varying degree of DPPH radical scavenging activity and their IC50 values range between 4.05-369.30 µM. The compounds 17, 28, 18, 14, 8, 15, 12, 2, 29, and 7 exhibited IC50 values ranging between 4.05 ± 0.06-24.42 ± 0.86 µM which are superior to standard n-propylgallate (IC50 = 30.12 ± 0.27 µM). Selected compounds have shown a varying degree of superoxide anion radical scavenger activity and their IC50 values range between 91.23-406.90 µM. The compounds 28 8, 17, 15, and 14, showed IC50 values between 91.23 ± 1.2-105.31 ± 2.29 µM which are superior to standard n-propylgallate (IC50 = 106.34 ± 1.6 µM).

Keywords: 2, 4, 6-Trichlorophenylhydrazine Schiff bases, DPPH radical, superoxide anion scavengers, trichlorophenylhydrazine, radical scavenging, propylgallate, antituberculosis, antifungal, rodenticides