On Chemical Structures with Potent Antiepileptic/Anticonvulsant Profile

Title:On Chemical Structures with Potent Antiepileptic/Anticonvulsant Profile

Volume: 12 Issue: 7

Author(s): M. N. Aboul-Enein, A. A. El-Azzouny, O. A. Saleh and Y. A. Maklad

Affiliation:

Keywords: Epilepsy, Mechanism of action of antiepileptics, Antiepileptics, Anticonvulsants, congenital, anticonvulsant, Tonic-Clonic Seizures, Generalized Seizures, Myoclonic Seizures, Benzodiazepines

Abstract: Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. There has been a considerable interest in the development of many antiepileptic and anticonvulsant agents for controlling epilepsy with fewer side effects and improvement of quality of life. Since the terms antiepileptics /anticonvulsants are used interchangeably, this article reviews their classification according to the chemical structure into: hydantoins, oxazolidinediones, succinimides, barbiturates, amides, benzodiazepines, valproic acid and its derivatives, GABAanalogues, cycloalkanes, semicarbazones, γ butyrolactones (GBLs), imidaquinazolines and pyrrolidine derivatives as well as miscellaneous compounds. In addition, the review discusses the different mechanisms of action of antiepileptic and anticonvulsant agents.

Cite this article as:

N. Aboul-Enein M., A. El-Azzouny A., A. Saleh O. and A. Maklad Y., On Chemical Structures with Potent Antiepileptic/Anticonvulsant Profile, Mini-Reviews in Medicinal Chemistry 2012; 12 (7) . https://dx.doi.org/10.2174/138955712800626665