Anticancer Activity and Anti-inflammatory Studies of 5-Aryl-1,4-benzodiazepine Derivatives

Title:Anticancer Activity and Anti-inflammatory Studies of 5-Aryl-1,4-benzodiazepine Derivatives

Volume: 12 Issue: 6

Author(s): Cortez-Maya Sandra, Cortes Cortes Eduardo, Hernandez-Ortega Simon, Ramirez Apan Teresa, Nieto Camacho Antonio, Irina V. Lijanova and Martinez-Garcia Marcos

Affiliation:

Keywords: Anticancer activity, Anti-inflammatory, 1, 4-benzodiazepines, Myeloperoxidase

Abstract: A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine.

Cite this article as:

Sandra Cortez-Maya, Cortes Eduardo Cortes, Simon Hernandez-Ortega, Apan Teresa Ramirez, Camacho Antonio Nieto, V. Lijanova Irina and Marcos Martinez-Garcia, Anticancer Activity and Anti-inflammatory Studies of 5-Aryl-1,4-benzodiazepine Derivatives, Anti-Cancer Agents in Medicinal Chemistry 2012; 12 (6) . https://dx.doi.org/10.2174/187152012800617713