Risk Factors for Pneumococcal Nasopharyngeal Colonization Before and After Pneumococcal Conjugate Vaccination in Persons with HIV: Brief Report

Title:Risk Factors for Pneumococcal Nasopharyngeal Colonization Before and After Pneumococcal Conjugate Vaccination in Persons with HIV: Brief Report

Volume: 10 Issue: 3

Author(s): Kristina Obrink-Hansen, Ole S. Søgaard, Zitta B. Harboe and Henrik C. Schonheyder

Affiliation:

Keywords: HIV, Nasopharyngeal colonization, Pneumococcal vaccination, Risk factors, Smoking, S. Pneumoniae.

Abstract: HIV-infected individuals have excess rates of invasive pneumococcal disease. We investigated risk factors for nasopharyngeal pneumococcal colonization at baseline and after 9 months in 96 HIV patients immunized twice with 7- valent pneumococcal conjugate vaccine ±1mg CPG 7909.

In total, 22 patients (23%) were colonized, 11 at baseline only, four at both baseline and 9 months, and seven at 9 months only. Compared to non-colonized patients, more colonized patients were smokers, had lower CD4+ nadir and had an AIDS-diagnosis. Immunization, antiretroviral treatment and the CPG adjuvant had no impact on colonization. These results suggest preventive strategies in addition to pneumococcal immunization.

Cite this article as:

Obrink-Hansen Kristina, S. Søgaard Ole, B. Harboe Zitta and C. Schonheyder Henrik, Risk Factors for Pneumococcal Nasopharyngeal Colonization Before and After Pneumococcal Conjugate Vaccination in Persons with HIV: Brief Report, Current HIV Research 2012; 10 (3) . https://dx.doi.org/10.2174/157016212800618101