Abstract
A convenient and efficient procedure for the synthesis of 1-amidoalkyl-2-naphthols by condensation of β- naphthol, aldehydes and amid/urea in the presence of POCl3/ Na2B4O7 is described. This method offers several advantages including low cost and easy availability of the catalyst, environmentally friendly procedure and easy work-up under solvent-free conditions.
Keywords: 1-Amidoalkyl-2-naphthols, borax, multicomponent reactions, POCl3, HIV, protease inhibitors, Iodine, temperatures, biological screening, benzaldehyde
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