Epimerization Free Synthesis of O-Acyl Isodipeptides Employing COMU

Title:Epimerization Free Synthesis of O-Acyl Isodipeptides Employing COMU

Volume: 19 Issue: 4

Author(s): M. Samarasimhareddy, Hosahalli P. Hemantha, Kuppanna Ananda and Vommina V. Sureshbabu

Affiliation:

Keywords: O-acyl isodipeptide, click peptide, difficult sequence, COMU, esterification

Abstract: O-Acyl isodipeptides are prepared by coupling Boc-Ser/Thr-OBzl with Fmoc-Xaa-OH employing COMU, well known third generation peptide coupling agent. The reaction proceeds with high yield and the chemical homogeneity of the synthesized molecules were established via chiral HPLC analyses. The O-acyl isodipeptide units play crucial role in the success of ‘click peptide’ protocol employed for assembling ‘difficult sequence’ peptides.

Cite this article as:

Samarasimhareddy M., P. Hemantha Hosahalli, Ananda Kuppanna and V. Sureshbabu Vommina, Epimerization Free Synthesis of O-Acyl Isodipeptides Employing COMU, Protein & Peptide Letters 2012; 19 (4) . https://dx.doi.org/10.2174/092986612799789413