A Clean Procedure for Synthesis of Pyrido[d]Pyrimidine Derivatives Under Solvent-Free Conditions Catalyzed by ZrO2 Nanoparticles

Title:A Clean Procedure for Synthesis of Pyrido[d]Pyrimidine Derivatives Under Solvent-Free Conditions Catalyzed by ZrO2 Nanoparticles

Volume: 15 Issue: 5

Author(s): Shahrzad Abdolmohammadi and Saeed Balalaie

Affiliation:

Keywords: Solvent-free, tandem knoevenagel-michael addition, tetrahydropyrido[d]pyrimidine, ZrO2 nanoparticles

Abstract: A simple one-pot method for the preparation of 7-amino-2,4-dioxo-5-aryl-1,2,3,4-tetrahydropyrido[2,3- d]pyrimidine-6-carbonitriles 4 from aromatic aldehydes, malononitrile and 4(6)-aminouracil in the presence of ZrO2 nanoparticles (ZrO2 NPs) as an efficient heterogeneous catalyst is described. The procedure has the advantages of high yields (86-97%), short reaction time (2h) and an environmentally friendly specificity....

Cite this article as:

Abdolmohammadi Shahrzad and Balalaie Saeed, A Clean Procedure for Synthesis of Pyrido[d]Pyrimidine Derivatives Under Solvent-Free Conditions Catalyzed by ZrO2 Nanoparticles, Combinatorial Chemistry & High Throughput Screening 2012; 15 (5) . https://dx.doi.org/10.2174/138620712800194486