Patented Routes for the Preparation of the Morphinan Derivatives Hydromorphone and Hydrocodone Via Catalytic Isomerization

Title:Patented Routes for the Preparation of the Morphinan Derivatives Hydromorphone and Hydrocodone Via Catalytic Isomerization

Volume: 1 Issue: 1

Author(s): Alba E. Diaz-Alvarez and Victorio Cadierno

Affiliation:

Keywords: Codeine, hydrocodone, hydromorphone, morphinan derivatives, morphine, redox isomerization of allylic alcohols, transition-metal complexes.

Abstract: Hydromorphone and hydrocodone are widely used narcotic analgesics. In this mini-review article, processes for the preparation of these semi-synthetic opioids from the naturally occurring opiates morphine and codeine, respectively, via catalytic isomerization of the allylic alcohol unit of the latter are discussed. Relevant patents in the field are presented.

Cite this article as:

Diaz-Alvarez E. Alba and Cadierno Victorio, Patented Routes for the Preparation of the Morphinan Derivatives Hydromorphone and Hydrocodone Via Catalytic Isomerization, Recent Patents on Catalysis (Discontinued) 2012; 1 (1) . https://dx.doi.org/10.2174/2211548X11201010043

DOI https://dx.doi.org/10.2174/2211548X11201010043	Print ISSN 2211-548X
Publisher Name Bentham Science Publisher	Online ISSN 2211-5498