Using Extracellular Matrix-Derived Peptides to Alter the Microenvironment for Myocardial Repair

Title:Using Extracellular Matrix-Derived Peptides to Alter the Microenvironment for Myocardial Repair

Volume: 10 Issue: 3

Author(s): Shirley S. Mihardja and Randall J. Lee

Affiliation:

Keywords: Extracellular matrix, myocardial infarction, tissue engineering, cardiac repair, angiogenesis

Abstract: Myocardial repair remains a major challenge for both cellular and tissue engineering approaches. Several studies have been conducted looking at utilizing extracellular matrix-based therapies to promote repair after a myocardial infarction. In this review, strategies for treating myocardial infarctions using extracellular matrix-derived peptides are discussed. Using an ischemia/reperfusion myocardial infarction rodent model, we showed that extracellular-matrix-derived peptides were able to induce angiogenesis and alter the negative remodeling seen after a myocardial infarction. This therapy opens up a potentially new non-invasive strategy for repairing damaged cardiac tissue.

Cite this article as:

S. Mihardja Shirley and J. Lee Randall, Using Extracellular Matrix-Derived Peptides to Alter the Microenvironment for Myocardial Repair, Current Vascular Pharmacology 2012; 10 (3) . https://dx.doi.org/10.2174/157016112799959341