Animal Models for Microbicide Studies

Ronald      S. Veazey; Robin      J Shattock; Per      Johan Klasse; John      P. Moore

doi:10.2174/157016212799304715

Abstract

There have been encouraging recent successes in the development of safe and effective topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-retroviral drugs. However, much work remains to be accomplished before a microbicide becomes a standard element of prevention science strategies. Animal models should continue to play an important role in pre-clinical testing, with emphasis on safety, pharmacokinetic and efficacy testing.

Keywords: HIV, animal models, HIV transmission, mucosal transmission, vagina, rectum, microbicide, culture, cells, therapy

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Current HIV Research

Title: Animal Models for Microbicide Studies

Volume: 10 Issue: 1

Author(s): Ronald S. Veazey, Robin J Shattock, Per Johan Klasse and John P. Moore

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Keywords: HIV, animal models, HIV transmission, mucosal transmission, vagina, rectum, microbicide, culture, cells, therapy

Abstract: There have been encouraging recent successes in the development of safe and effective topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-retroviral drugs. However, much work remains to be accomplished before a microbicide becomes a standard element of prevention science strategies. Animal models should continue to play an important role in pre-clinical testing, with emphasis on safety, pharmacokinetic and efficacy testing.

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S. Veazey Ronald, J Shattock Robin, Johan Klasse Per and P. Moore John, Animal Models for Microbicide Studies, Current HIV Research 2012; 10 (1) . https://dx.doi.org/10.2174/157016212799304715