Proteins as Networks: A Mesoscopic Approach Using Haemoglobin Molecule as Case Study

Title: Proteins as Networks: A Mesoscopic Approach Using Haemoglobin Molecule as Case Study

Volume: 6 Issue: 4

Author(s): Alessandro Giuliani, Luisa Di Paola and Roberto Setola

Affiliation:

Abstract: Protein structures allow for a straightforward representation in terms of graph theory being the nodes the aminoacid residues and the edges the scoring of a spatial contact between the node pairs. Such a representation allows for a direct use in the realm of protein science of the vast repertoire of graph invariants developed in the analysis of complex networks. In this work we give a general overview of the protein as networks paradigm with a special emphasis on haemoglobin where the most important features of protein systems like allostery, protein-protein contacts and differential effect of mutations were demonstrated to be amenable to a graph theory oriented translation.

Cite this article as:

Giuliani Alessandro, Di Paola Luisa and Setola Roberto, Proteins as Networks: A Mesoscopic Approach Using Haemoglobin Molecule as Case Study, Current Proteomics 2009; 6 (4) . https://dx.doi.org/10.2174/157016409789973743