Kisspeptin: Paving the Way to a New Therapeutic Avenue in Reproduction

Title: Kisspeptin: Paving the Way to a New Therapeutic Avenue in Reproduction

Volume: 3 Issue: 2

Author(s): Channa N. Jayasena, George Tharakan and Waljit S. Dhillo

Affiliation:

Keywords: Kisspeptin, metastin, GPR54, gonadotrophin, infertility, hypothalamus, GnRH

Abstract: Dysfunction of the hypothalamo-pituitary gonadal (HPG) axis may result in a variety of disorders, ranging from precocious puberty to infertility. Current therapies for such disorders have varying degrees of success, and are associated with adverse effects and / or practical limitations. The recent identification of Kisspeptin as a critical regulator of reproduction, may offer a new avenue for therapeutically manipulating the HPG axis. This article provides a synopsis of the role of Kisspeptin and the Kisspeptin receptor in reproduction, with an emphasis on potential areas of its exploitation as a therapeutic or diagnostic tool. This article also reviews some of the recent patents related to the field.

Cite this article as:

Jayasena N. Channa, Tharakan George and Dhillo S. Waljit, Kisspeptin: Paving the Way to a New Therapeutic Avenue in Reproduction, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) 2009; 3 (2) . https://dx.doi.org/10.2174/187221409788452354