Synthesis, Characterisation, Anti-Microbial Activity and Docking Studies of Novel Dispiro- Oxindolopyrrolidines

Title: Synthesis, Characterisation, Anti-Microbial Activity and Docking Studies of Novel Dispiro- Oxindolopyrrolidines

Volume: 3 Issue: 1

Author(s): Adukamparai R. Suresh Babu, Raghavachary Raghunathan, Kuppamuthu Kumaresan and Nanjian Raaman

Affiliation:

Keywords: 1,3-dipole/kwd, >, azomethine ylide, oxindole, pyrrolizidines, antimicrobial activity

Abstract: 2-arylidene-1,3-indanediones undergo a regioselective 1,3-dipolar cycloaddition reaction with the azomethine ylide derived from isatin and proline to give a rare class of novel complex dispirooxindolopyrrolizidines in better yield under microwave irradiation than classical heating. X-ray crystal structure analysis of one of the product confirms the structure and regiochemical outcome of the cycloaddition reaction. Anti-microbial activity studies were carried out with all the newly synthesized dispiro-oxindolopyrrolizidines.

Cite this article as:

Suresh Babu R. Adukamparai, Raghunathan Raghavachary, Kumaresan Kuppamuthu and Raaman Nanjian, Synthesis, Characterisation, Anti-Microbial Activity and Docking Studies of Novel Dispiro- Oxindolopyrrolidines, Current Chemical Biology 2009; 3 (1) . https://dx.doi.org/10.2174/2212796810903010112