Abstract
There is a growing body of evidence that oxidative stress mediated by reactive oxygen species plays an important role in the pathogenesis of various kinds of allergic and non-allergic inflammation. These data suggest that blocking reactive oxygen species should be useful for amelioration of allergic or non-allergic inflammation in the respiratory and intestinal tracts. In addition, the modulation of oxidative stress-related molecules, such as inducible nitric oxide synthase and redox-sensitive transcriptional factors, may be useful for the regulation of these inflammatory responses. In this review, we have summarized the recent advances in the prevention of allergic or non-allergic inflammation, especially the diesel exhaust particle-induced respiratory allergic response and dextran sulfate sodium-induced intestinal inflammation in rodents.
Keywords: antioxidant, inducible nitric oxide synthase, nuclear factor, oxidative stress
Current Drug Targets - Inflammation & Allergy
Title: Oxidative Stress-Related Molecules as a Therapeutic Target for Inflammatory and Allergic Diseases
Volume: 4 Issue: 4
Author(s): Y. Naito, H. Takano and T. Yoshikawa
Affiliation:
Keywords: antioxidant, inducible nitric oxide synthase, nuclear factor, oxidative stress
Abstract: There is a growing body of evidence that oxidative stress mediated by reactive oxygen species plays an important role in the pathogenesis of various kinds of allergic and non-allergic inflammation. These data suggest that blocking reactive oxygen species should be useful for amelioration of allergic or non-allergic inflammation in the respiratory and intestinal tracts. In addition, the modulation of oxidative stress-related molecules, such as inducible nitric oxide synthase and redox-sensitive transcriptional factors, may be useful for the regulation of these inflammatory responses. In this review, we have summarized the recent advances in the prevention of allergic or non-allergic inflammation, especially the diesel exhaust particle-induced respiratory allergic response and dextran sulfate sodium-induced intestinal inflammation in rodents.
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Cite this article as:
Naito Y., Takano H. and Yoshikawa T., Oxidative Stress-Related Molecules as a Therapeutic Target for Inflammatory and Allergic Diseases, Current Drug Targets - Inflammation & Allergy 2005; 4 (4) . https://dx.doi.org/10.2174/1568010054526269
DOI https://dx.doi.org/10.2174/1568010054526269 |
Print ISSN 1568-010X |
Publisher Name Bentham Science Publisher |
Online ISSN 1568-010X |
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