Macromolecular and Nanotechnological Modification of Camptothecin and its Analogs to Improve the Efficacy

Title: Macromolecular and Nanotechnological Modification of Camptothecin and its Analogs to Improve the Efficacy

Volume: 2 Issue: 3

Author(s): Hiraku Onishi and Yoshiharu Machida

Affiliation:

Keywords: camptothecin (cpt), analog, macromolecular chemical modification, nanotechnological formulation, enhanced permeability and retention (epr) effect

Abstract: Camptothecin (CPT) and its analogs are some of the most potent antitumor agents known. However, their poor water-solubility and high toxicity require changes of their physicochemical and biological characteristics. Active lactone forms have provoked interest in the utility of CPT and its analogs again. Macromolecular chemical modifications and nanotechnological formulations have been used to obtain improved systems of CPT-related compounds. In these systems, one of the most important concepts is the enhanced permeability and retention (EPR) effect. The outcomes obtained by these approaches are displayed by introducing concrete examples.

Cite this article as:

Onishi Hiraku and Machida Yoshiharu, Macromolecular and Nanotechnological Modification of Camptothecin and its Analogs to Improve the Efficacy, Current Drug Discovery Technologies 2005; 2 (3) . https://dx.doi.org/10.2174/1570163054866891