Novel Targets for Drugs in Schizophrenia

Title: Novel Targets for Drugs in Schizophrenia

Volume: 6 Issue: 4

Author(s): J.M. Stone and L.S. Pilowsky

Affiliation:

Keywords: Schizophrenia, antipsychotic, dopamine, glutamate, NMDA, AMPA, acetylcholine, serotonin

Abstract: Since the discovery of the first antipsychotic drug, chlorpromazine, in the early 1950s, all effective antipsychotic drugs have been found to share the common property of dopamine D2 receptor antagonism. There has been some suggestion that simple D2 receptor antagonism may not confer optimal antipsychotic efficacy. Currently available antipsychotic drugs leave many symptoms of the illness untreated and cause unacceptable side effects. Recent research in schizophrenia suggests a number of potential new non-D2 targets for pharmacotherapy including glutamate, acetylcholine and serotonin neurotransmitter systems. This review summarises the main neurochemical theories of schizophrenia, and, in the light of these, examines possible therapeutic targets for new antipsychotic drugs.

Cite this article as:

J.M. Stone and L.S. Pilowsky , Novel Targets for Drugs in Schizophrenia, CNS & Neurological Disorders - Drug Targets 2007; 6 (4) . https://dx.doi.org/10.2174/187152707781387323