Transforming Growth Factor-β (TGF-β ) and its Role in the Pathogenesis of Systemic Sclerosis: A Novel Target for Therapy?

Chris T. Derk

doi:10.2174/187221307780979883

Abstract

One of the growth factors that appear to play a crucial role in the pathogenesis of systemic sclerosis is TGF-β. The three functionally and structurally similar human isoforms of TGF-β play important roles in embryonic development, in the regulation of tissue repair following injury and in immune responses. Systemic sclerosis fibroblasts express increased levels of TGF-β receptors on their surface which in turn results in increased signalimg of TGF-β induced collagen gene expression. Some of the patents and intricate pathways that mediate the stimulation of collagen gene expression by TGF-β have recently been described and a potential inhibition of these pathways may lead to novel therapeutic targets for systemic sclerosis.

Keywords: Systemic sclerosis, scleroderma, fibrosis, transforming growth factor-beta

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