Targeting Invasion and Egress: From Tools to Drugs?

R.   E.   Morgan; K   M.   Evans; S.      Patterson; F.      Catti; G.   E.   Ward; N.   J.   Westwood

doi:10.2174/138945007779315678

Abstract

A recent resurgence in the use of compounds to study essential biological processes raises important questions concerning the link between fundamental research and drug development. This article discusses many of the issues involved, in the context of host cell invasion and egress by parasites of the Phylum Apicomplexa. In addition, an overview of the key steps in invasion and egress is provided with a particular emphasis on potential parasite protein drug targets.

Keywords: Apicomplexa, Invasion, Egress, Toxoplasma, Plasmodium, Chemical genetics, Drug discovery, Inhibitors

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Current Drug Targets

Title: Targeting Invasion and Egress: From Tools to Drugs?

Volume: 8 Issue: 1

Author(s): R. E. Morgan, K M. Evans, S. Patterson, F. Catti, G. E. Ward and N. J. Westwood

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Keywords: Apicomplexa, Invasion, Egress, Toxoplasma, Plasmodium, Chemical genetics, Drug discovery, Inhibitors

Abstract: A recent resurgence in the use of compounds to study essential biological processes raises important questions concerning the link between fundamental research and drug development. This article discusses many of the issues involved, in the context of host cell invasion and egress by parasites of the Phylum Apicomplexa. In addition, an overview of the key steps in invasion and egress is provided with a particular emphasis on potential parasite protein drug targets.

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Morgan E. R., Evans M. K, Patterson S., Catti F., Ward E. G. and Westwood J. N., Targeting Invasion and Egress: From Tools to Drugs?, Current Drug Targets 2007; 8 (1) . https://dx.doi.org/10.2174/138945007779315678