Discovery ofβ-Glucosidase Inhibitors from a Chemically Engineered Extract Prepared through Ethanolysis

Title: Discovery ofβ-Glucosidase Inhibitors from a Chemically Engineered Extract Prepared through Ethanolysis

Volume: 8 Issue: 1

Author(s): I. Ayelen Ramallo, Manuel Gonzalez Sierra and Ricardo L. E. Furlan

Affiliation:

Keywords: Chemically engineered extracts, Ethanolysis, TLC biodetection, -glucosidase inhibition, ethyl p-cumarate, thin layer chromatography, bromine, arylsulfonyl chlorides, hydrazine, antifungal

Abstract: A series of vegetal extracts have been chemically altered by ethanolysis. The effect of the reaction on the inhibition of the enzyme β-glucosidase properties of the mixtures was studied using thin layer chromatography (TLC) with biodetection. Glucosidase inhibitory activity guided fractionation of one of the produced chemically engineered extracts led to the isolation of apigenin and ethyl p-cumarate. Both compounds were generated during the chemical modification step.

Cite this article as:

Ayelen Ramallo I., Gonzalez Sierra Manuel and L. E. Furlan Ricardo, Discovery ofβ-Glucosidase Inhibitors from a Chemically Engineered Extract Prepared through Ethanolysis, Medicinal Chemistry 2012; 8 (1) . https://dx.doi.org/10.2174/157340612799278559