Synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one Catalyzed by Silica Sulfuric Acid Under Solvent Free Condition

Ya-Li      Song; Zhi-Ping      Lin; Guo-Feng      Chen; Quan-Lin      Liu; Ji-Tai      Li

doi:10.2174/157017812800221816

Abstract

An efficient synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one derivatives via the three-component condensation of aromatic aldehyde, 2-naphthol and 5,5-dimethyl-1,3-cyclohexanedione was carried out in 72- 85% yields at 80 °C under solvent free condition using silica sulfuric acid (SSA) as catalyst.

Keywords: Silica sulfuric acid, three-component condensation, xanthene, aldehyde, antibacterial, anti-inflammatory, antiviral, naphthol, sulfuric acid, silica

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Letters in Organic Chemistry

Title: Synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one Catalyzed by Silica Sulfuric Acid Under Solvent Free Condition

Volume: 9 Issue: 2

Author(s): Ya-Li Song, Zhi-Ping Lin, Guo-Feng Chen, Quan-Lin Liu and Ji-Tai Li

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Keywords: Silica sulfuric acid, three-component condensation, xanthene, aldehyde, antibacterial, anti-inflammatory, antiviral, naphthol, sulfuric acid, silica

Abstract: An efficient synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one derivatives via the three-component condensation of aromatic aldehyde, 2-naphthol and 5,5-dimethyl-1,3-cyclohexanedione was carried out in 72- 85% yields at 80 °C under solvent free condition using silica sulfuric acid (SSA) as catalyst.

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Song Ya-Li, Lin Zhi-Ping, Chen Guo-Feng, Liu Quan-Lin and Li Ji-Tai, Synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one Catalyzed by Silica Sulfuric Acid Under Solvent Free Condition, Letters in Organic Chemistry 2012; 9 (2) . https://dx.doi.org/10.2174/157017812800221816