Structure and Functions of Influenza Virus Neuraminidase

Jianzhi      Gong; Wenfang      Xu; Jie      Zhang

doi:10.2174/092986707779313444

Abstract

Influenza is a disease that deeply affects millions of people every year. There has not been any drug effective against all strains. Neuraminidase (NA) is the major surface glycoprotein of the influenza virus, which possesses critical enzymatic activity and has been considered as a suitable target for designing agents against influenza viruses. Here we review the structure and functions of this enzyme and touch upon the structureactivity relationship (SAR) of existing influenza neuraminidase inhibitors (NAIs).

Keywords: Influenza virus, Neuraminidase, Structure, Functions, Neuraminidase inhibitors, Structure-activity relationship

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Current Medicinal Chemistry

Title: Structure and Functions of Influenza Virus Neuraminidase

Volume: 14 Issue: 1

Author(s): Jianzhi Gong, Wenfang Xu and Jie Zhang

Affiliation:

Keywords: Influenza virus, Neuraminidase, Structure, Functions, Neuraminidase inhibitors, Structure-activity relationship

Abstract: Influenza is a disease that deeply affects millions of people every year. There has not been any drug effective against all strains. Neuraminidase (NA) is the major surface glycoprotein of the influenza virus, which possesses critical enzymatic activity and has been considered as a suitable target for designing agents against influenza viruses. Here we review the structure and functions of this enzyme and touch upon the structureactivity relationship (SAR) of existing influenza neuraminidase inhibitors (NAIs).

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Gong Jianzhi, Xu Wenfang and Zhang Jie, Structure and Functions of Influenza Virus Neuraminidase, Current Medicinal Chemistry 2007; 14 (1) . https://dx.doi.org/10.2174/092986707779313444