Efficient Syntheses of exo-Granisetron Hydrochloride and other Potential Impurities Present in Granisetron Hydrochloride, an Anti-Emetic Drug

Eda      V.R. Vishnu; Suju      Joseph; Abayee      K. Srinivasana; Ramesh      S. Gania; Govindabur      R. Reddy; Patakokila      V. Rao; Vilas      H. Dahanukara; Josyula      Ramanatham; Nayakanti      Devanna

doi:10.2174/157017811799304142

Abstract

European Pharmacopeia mentions about nine potential impurities in Granisetron hydrochloride. These impurities need to be controlled in the API as described in the Pharmacopeia. Elegant syntheses of four potential impurities in Granisetron hydrochloride are disclosed.

Keywords: Impurity-A, impurity-C, exo-Granisetron (impurity-F), impurity-I, residual solvents, hydrochloride, alkylation, chemotherapy, Harmonization, azodicarboxylate

« Previous Next »

Rights & Permissions Print Cite

Letters in Organic Chemistry

Title: Efficient Syntheses of exo-Granisetron Hydrochloride and other Potential Impurities Present in Granisetron Hydrochloride, an Anti-Emetic Drug

Volume: 8 Issue: 10

Author(s): Eda V.R. Vishnu, Suju Joseph, Abayee K. Srinivasana, Ramesh S. Gania, Govindabur R. Reddy, Patakokila V. Rao, Vilas H. Dahanukara, Josyula Ramanatham and Nayakanti Devanna

Affiliation:

Keywords: Impurity-A, impurity-C, exo-Granisetron (impurity-F), impurity-I, residual solvents, hydrochloride, alkylation, chemotherapy, Harmonization, azodicarboxylate

Abstract: European Pharmacopeia mentions about nine potential impurities in Granisetron hydrochloride. These impurities need to be controlled in the API as described in the Pharmacopeia. Elegant syntheses of four potential impurities in Granisetron hydrochloride are disclosed.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

V.R. Vishnu Eda, Joseph Suju, K. Srinivasana Abayee, S. Gania Ramesh, R. Reddy Govindabur, V. Rao Patakokila, H. Dahanukara Vilas, Ramanatham Josyula and Devanna Nayakanti, Efficient Syntheses of exo-Granisetron Hydrochloride and other Potential Impurities Present in Granisetron Hydrochloride, an Anti-Emetic Drug, Letters in Organic Chemistry 2011; 8 (10) . https://dx.doi.org/10.2174/157017811799304142