Recent Advances in the Field of 16-Membered Macrolide Antibiotics

Title: Recent Advances in the Field of 16-Membered Macrolide Antibiotics

Volume: 11 Issue: 12

Author(s): W. Cui and S. Ma

Affiliation:

Keywords: 16-membered macrolides, structural flexibility, mycarose moiety, antimicrobial properties, resistant strains, resistance mechanism, tylosin, leucomycin, bacterial resistance, gastrointestinal

Abstract: The continuing emergence of bacterial resistance has provided an incentive for recent intensified research on macrolide antibiotics. Belonging to the macrolide family, 16-membered macrolides also experience a renewed interest in further exploration. The medicinal potential of 16-membered macrolides in search for new antibacterials stems from some advantages over 14-membered macrolides, such as gastrointestinal tolerability, structural flexibility, and lack of inducible resistance. Thus, compared with abundant articles on various 14-membered macrolide derivatives in the literature, this review will highlight some representative 16-membered macrolide antibiotics and their recently discovered analogs. Furthermore, the action and resistance mechanisms of 16-membered macrolide antibiotics will be elucidated as well to assist the drug design.

Cite this article as:

Cui W. and Ma S., Recent Advances in the Field of 16-Membered Macrolide Antibiotics, Mini-Reviews in Medicinal Chemistry 2011; 11 (12) . https://dx.doi.org/10.2174/138955711797247734