Antiretroviral and Antituberculosis Therapy in HIV-TB Co-Infected Children

Title: Antiretroviral and Antituberculosis Therapy in HIV-TB Co-Infected Children

Volume: 7 Issue: 3

Author(s): Amy L. Slogrove, Helena Rabie and Mark F. Cotton

Affiliation:

Keywords: Antiretroviral therapy, antituberculosis therapy, TB-HIV co-infection, children

Abstract: HIV-infected children experience a high burden of tuberculosis. With recent advances in international pediatric HIV treatment guidelines significant numbers of infants and children will require simultaneous treatment for both TB and HIV. This article attempts to concisely outline strategies for effective co-treatment of both infections. Rifamycins, an essential component of short course TB chemotherapy, alter the metabolism of a number of antiretroviral drugs. These interactions and their consequences are considered. Options for antiretroviral therapy and the optimal timing of its initiation in the presence of antituberculosis therapy are discussed.

Cite this article as:

Slogrove Amy L., Rabie Helena and Cotton Mark F., Antiretroviral and Antituberculosis Therapy in HIV-TB Co-Infected Children, Current Pediatric Reviews 2011; 7 (3) . https://dx.doi.org/10.2174/157339611796548474