Targeting Signaling Pathways in Multiple Myeloma

Title: Targeting Signaling Pathways in Multiple Myeloma

Volume: 7 Issue: 6

Author(s): Cavallo Federica, Palumbo Antonio, Tricot Guido and Boccadoro Mario

Affiliation:

Keywords: Interleukin-6, VEGF, MAPK signaling pathways, Bcl-2 homology, Post Transcriptional Pathways

Abstract: Multiple myeloma (MM) is an incurable malignancy of terminally differentiated B-cells accounting for approximately 1 to 2% of all human cancers. The development of MM is believed to be a multistep transformation process that leads to progressive accumulation of genetic alterations. The interaction between MM and bone marrow (BM) microenviroment triggers multiple proliferative and antiapoptotic signaling pathways. Here we discuss the current understanding of signaling pathways, and their potential implication in targeted therapies in MM.

Cite this article as:

Federica Cavallo, Antonio Palumbo, Guido Tricot and Mario Boccadoro, Targeting Signaling Pathways in Multiple Myeloma, Current Pharmaceutical Biotechnology 2006; 7 (6) . https://dx.doi.org/10.2174/138920106779116883