A Novel, Unusual Acid Catalyzed Route to Substituted 1,4-dihydropyridine via Double Decarboxylation

Jacob      Porter; Graham      Radomski; Joel      Seagren; Benjamin      Batura; Samuel      David

doi:10.2174/157017811799304278

Abstract

A simple and high yield route to 3,4,5-trisubstituted 1,4-dihydropyridine systems via an interesting intermolecular condensation and double decarboxylation is described.

Keywords: 3,4,5-trisubstituted, 1,4-dihydropyridines, double decarboxylation, enamine, heterocycles, intermolecular condensation, tandem reaction, nifedipine), calcium, ethylidene, dimethyl

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Letters in Organic Chemistry

Title: A Novel, Unusual Acid Catalyzed Route to Substituted 1,4-dihydropyridine via Double Decarboxylation

Volume: 8 Issue: 9

Author(s): Jacob Porter, Graham Radomski, Joel Seagren, Benjamin Batura and Samuel David

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Keywords: 3,4,5-trisubstituted, 1,4-dihydropyridines, double decarboxylation, enamine, heterocycles, intermolecular condensation, tandem reaction, nifedipine), calcium, ethylidene, dimethyl

Abstract: A simple and high yield route to 3,4,5-trisubstituted 1,4-dihydropyridine systems via an interesting intermolecular condensation and double decarboxylation is described.

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Porter Jacob, Radomski Graham, Seagren Joel, Batura Benjamin and David Samuel, A Novel, Unusual Acid Catalyzed Route to Substituted 1,4-dihydropyridine via Double Decarboxylation, Letters in Organic Chemistry 2011; 8 (9) . https://dx.doi.org/10.2174/157017811799304278